Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline KLM
Cheapest Month June
Cheapest Day of the Week Wednesday
Cheapest Airline KLM

The cheapest airline(s) flying from Panama City to Madrid is KLM.

  • KLM KLM
  • Avianca Avianca
  • Air Europa Air Europa
  • Air France Air France
  • Iberia Iberia
  • Turkish Airlines Turkish Airlines
  • American Airlines American Airlines
  • United Airlines United Airlines
  • Aeromexico Aeromexico
  • Emirates Emirates
Cheapest Month June

Travel Period: May 2025 - April 2026

The cheapest month(s) to fly from Panama City to Madrid is June.

  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
  • Dec 2025
  • Jan 2026
  • Feb 2026
  • Mar 2026
  • Apr 2026
Cheapest Day of the Week Wednesday

The cheapest day(s) of the week to fly from Panama City to Madrid is Wednesday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Wed, 2 Apr, 2025

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    • Airline Filter by Airline
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      • Availability
        • M
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      • 20:25 PTY
        13:15 MAD
        9Hrs, 50m Direct
      • PTYPanama City Tocumen International Airport 20:25 - MAD 13:15 9h 50m Direct
      • PTYPanama City Tocumen International Airport 20:25
      • MADMadrid Barajas Airport 13:15
      • 9h 50m
      • Direct
      • Air Europa (UX 56)Boeing 787 9
      • Air Europa (UX 56)
        • M
        • -
        • -
        • -
        • F
        • S
        • -
      • Boeing 787 9
      • 20:25 PTY
        13:15 MAD
        9Hrs, 50m Direct
      • PTYPanama City Tocumen International Airport 20:25 - MAD 13:15 9h 50m Direct
      • PTYPanama City Tocumen International Airport 20:25
      • MADMadrid Barajas Airport 13:15
      • 9h 50m
      • Direct
      • Air Europa (UX 56)Boeing 787 8
      • Air Europa (UX 56)
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        • W
        • -
        • -
        • -
        • S
      • Boeing 787 8
      • 17:35 PTY
        10:25 MAD
        9Hrs, 50m Direct
      • PTYPanama City Tocumen International Airport 17:35 - MAD 10:25 9h 50m Direct
      • PTYPanama City Tocumen International Airport 17:35
      • MADMadrid Barajas Airport 10:25
      • 9h 50m
      • Direct
      • Iberia (IB 258)Airbus
      • Iberia (IB 258)
        • M
        • -
        • -
        • T
        • -
        • S
        • -
      • Airbus
      • 19:40 PTY
        19:20 MAD
        16Hrs, 40m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:40 - MAD 19:20 16h 40m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:40
        CDGParis Charles de Gaulle Airport 17:05
      • CDGParis Charles de Gaulle Airport 13:00
        MADMadrid Barajas Airport 19:20
      • 16h 40m (4h 05m)
      • 1 Stop CDG · Paris 4h 05m
      • Air France (AF 475)Airbus A359
        Air France (AF 1100)Airbus
      • Air France (AF 475)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 19:40 PTY
        16:45 MAD
        14Hrs, 05m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:40 - MAD 16:45 14h 05m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:40
        CDGParis Charles de Gaulle Airport 14:40
      • CDGParis Charles de Gaulle Airport 13:00
        MADMadrid Barajas Airport 16:45
      • 14h 05m (1h 40m)
      • 1 Stop CDG · Paris 1h 40m
      • Air France (AF 475)Airbus A359
        Air France (AF 1800)Airbus
      • Air France (AF 475)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 19:55 PTY
        19:20 MAD
        16Hrs, 25m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 19:20 16h 25m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 17:05
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 19:20
      • 16h 25m (3h 50m)
      • 1 Stop CDG · Paris 3h 50m
      • Air France (AF 475)Airbus A359
        Air France (AF 1100)Airbus
      • Air France (AF 475)
        • -
        • T
        • -
        • -
        • -
        • -
        • -
      • 19:55 PTY
        16:45 MAD
        13Hrs, 50m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 16:45 13h 50m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 14:40
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 16:45
      • 13h 50m (1h 25m)
      • 1 Stop CDG · Paris 1h 25m
      • Air France (AF 475)Airbus A359
        Air France (AF 1800)Airbus A220 300
      • Air France (AF 475)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 19:55 PTY
        16:45 MAD
        13Hrs, 50m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 16:45 13h 50m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 14:40
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 16:45
      • 13h 50m (1h 25m)
      • 1 Stop CDG · Paris 1h 25m
      • Air France (AF 475)Airbus A359
        Air France (AF 1800)Airbus
      • Air France (AF 475)
        • -
        • T
        • -
        • -
        • -
        • -
        • -
      • 19:55 PTY
        16:45 MAD
        13Hrs, 50m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 16:45 13h 50m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 14:40
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 16:45
      • 13h 50m (1h 25m)
      • 1 Stop CDG · Paris 1h 25m
      • Air France (AF 475)Airbus A359
        Air France (AF 1800)Airbus
      • Air France (AF 475)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 19:55 PTY
        19:20 MAD
        16Hrs, 25m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 19:20 16h 25m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 17:05
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 19:20
      • 16h 25m (3h 50m)
      • 1 Stop CDG · Paris 3h 50m
      • Air France (AF 475)Airbus A359
        Air France (AF 1100)Airbus A220 300
      • Air France (AF 475)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 19:55 PTY
        19:20 MAD
        16Hrs, 25m 1 Stop (CDG)
      • PTYPanama City Tocumen International Airport 19:55 - MAD 19:20 16h 25m 1 Stop (CDG) Paris
      • PTYPanama City Tocumen International Airport 19:55
        CDGParis Charles de Gaulle Airport 17:05
      • CDGParis Charles de Gaulle Airport 13:15
        MADMadrid Barajas Airport 19:20
      • 16h 25m (3h 50m)
      • 1 Stop CDG · Paris 3h 50m
      • Air France (AF 475)Airbus A359
        Air France (AF 1100)Airbus
      • Air France (AF 475)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 03:20 PTY
        23:30 MAD
        13Hrs, 10m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 03:20 - MAD 23:30 13h 10m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 03:20
        BOGBogota Airport 07:00
      • BOGBogota Airport 04:54
        MADMadrid Barajas Airport 23:30
      • 13h 10m (2h 06m)
      • 1 Stop BOG · Bogota 2h 06m
      • Avianca (AV 41)Airbus
        Avianca (AV 46)Boeing 787 8
      • Avianca (AV 41)
        • M
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        • F
        • -
        • S
      • 03:25 PTY
        23:30 MAD
        13Hrs, 05m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 03:25 - MAD 23:30 13h 05m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 03:25
        BOGBogota Airport 07:00
      • BOGBogota Airport 05:00
        MADMadrid Barajas Airport 23:30
      • 13h 05m (2h)
      • 1 Stop BOG · Bogota 2h
      • Avianca (AV 41)Airbus
        Avianca (AV 46)Boeing 787 8
      • Avianca (AV 41)
        • -
        • T
        • -
        • -
        • -
        • S
        • -
      • 09:13 PTY
        08:05 MAD
        15Hrs, 52m 1 Stop (IAD)
      • PTYPanama City Tocumen International Airport 09:13 - MAD 08:05 15h 52m 1 Stop (IAD) Washington
      • PTYPanama City Tocumen International Airport 09:13
        IADWashington Dulles International Airport 18:15
      • IADWashington Dulles International Airport 15:04
        MADMadrid Barajas Airport 08:05
      • 15h 52m (3h 11m)
      • 1 Stop IAD · Washington 3h 11m
      • Copa Airlines (CM 443)Boeing 737 Max 9 Passenger
        United Airlines (UA 260)Boeing 767 400
      • Copa Airlines (CM 443)
        • M
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        • S
      • 09:32 PTY
        09:35 MAD
        17Hrs, 03m 1 Stop (HAV)
      • PTYPanama City Tocumen International Airport 09:32 - MAD 09:35 17h 03m 1 Stop (HAV) Havana
      • PTYPanama City Tocumen International Airport 09:32
        HAVHavana Jose Marti Intl Airport 18:45
      • HAVHavana Jose Marti Intl Airport 13:17
        MADMadrid Barajas Airport 09:35
      • 17h 03m (5h 28m)
      • 1 Stop HAV · Havana 5h 28m
      • Copa Airlines (CM 345)Boeing 737 800
        Iberia (IB 274)Airbus Industrie 330 300
      • Copa Airlines (CM 345)
        • -
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        • -
        • -
        • F
        • -
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      • 09:45 PTY
        09:00 MAD
        16Hrs, 15m 1 Stop (EWR)
      • PTYPanama City Tocumen International Airport 09:45 - MAD 09:00 16h 15m 1 Stop (EWR) New York City
      • PTYPanama City Tocumen International Airport 09:45
        EWRNewark Liberty International Airport 19:25
      • EWRNewark Liberty International Airport 16:13
        MADMadrid Barajas Airport 09:00
      • 16h 15m (3h 12m)
      • 1 Stop EWR · New York City 3h 12m
      • United Airlines (UA 727)Boeing 737 Max 9 Passenger
        United Airlines (UA 51)Boeing 767 400
      • United Airlines (UA 727)
        • M
        • T
        • W
        • T
        • F
        • S
        • S
      • 09:50 PTY
        07:40 MAD
        14Hrs, 50m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 09:50 - MAD 07:40 14h 50m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 09:50
        BOGBogota Airport 15:10
      • BOGBogota Airport 11:20
        MADMadrid Barajas Airport 07:40
      • 14h 50m (3h 50m)
      • 1 Stop BOG · Bogota 3h 50m
      • Avianca (AV 59)Airbus
        Avianca (AV 26)Boeing 787 8
      • Avianca (AV 59)
        • -
        • T
        • -
        • T
        • -
        • S
        • -
      • 11:05 PTY
        11:10 MAD
        17Hrs, 05m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 11:05 - MAD 11:10 17h 05m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 11:05
        BOGBogota Airport 18:40
      • BOGBogota Airport 12:35
        MADMadrid Barajas Airport 11:10
      • 17h 05m (6h 05m)
      • 1 Stop BOG · Bogota 6h 05m
      • Avianca (AV 59)Airbus
        Avianca (AV 182)Boeing 787 8
      • Avianca (AV 59)
        • -
        • -
        • W
        • -
        • -
        • -
        • -
      • 11:05 PTY
        11:10 MAD
        17Hrs, 05m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 11:05 - MAD 11:10 17h 05m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 11:05
        BOGBogota Airport 18:40
      • BOGBogota Airport 12:35
        MADMadrid Barajas Airport 11:10
      • 17h 05m (6h 05m)
      • 1 Stop BOG · Bogota 6h 05m
      • Avianca (AV 8383)Airbus
        Avianca (AV 182)Boeing 787 8
      • Avianca (AV 8383)
        • -
        • -
        • -
        • -
        • F
        • -
        • S
      • 11:05 PTY
        07:40 MAD
        13Hrs, 35m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 11:05 - MAD 07:40 13h 35m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 11:05
        BOGBogota Airport 15:10
      • BOGBogota Airport 12:35
        MADMadrid Barajas Airport 07:40
      • 13h 35m (2h 35m)
      • 1 Stop BOG · Bogota 2h 35m
      • Avianca (AV 8383)Airbus
        Avianca (AV 26)Boeing 787 8
      • Avianca (AV 8383)
        • M
        • -
        • -
        • -
        • F
        • -
        • S
      • 11:05 PTY
        07:40 MAD
        13Hrs, 35m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 11:05 - MAD 07:40 13h 35m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 11:05
        BOGBogota Airport 15:10
      • BOGBogota Airport 12:35
        MADMadrid Barajas Airport 07:40
      • 13h 35m (2h 35m)
      • 1 Stop BOG · Bogota 2h 35m
      • Avianca (AV 59)Airbus
        Avianca (AV 26)Boeing 787 8
      • Avianca (AV 59)
        • -
        • -
        • W
        • -
        • -
        • -
        • -
      • 12:55 PTY
        10:50 MAD
        14Hrs, 55m 1 Stop (SJO)
      • PTYPanama City Tocumen International Airport 12:55 - MAD 10:50 14h 55m 1 Stop (SJO) San Jose
      • PTYPanama City Tocumen International Airport 12:55
        SJOSan Jose Juan Santamaria Airport 16:30
      • SJOSan Jose Juan Santamaria Airport 13:21
        MADMadrid Barajas Airport 10:50
      • 14h 55m (3h 09m)
      • 1 Stop SJO · San Jose 3h 09m
      • Copa Airlines (CM 779)Boeing 737 800
        Iberia (IB 244)Airbus Industrie A330 200
      • Copa Airlines (CM 779)
        • M
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        • T
        • F
        • -
        • S
      • 13:05 PTY
        12:45 MAD
        16Hrs, 40m 1 Stop (MIA)
      • PTYPanama City Tocumen International Airport 13:05 - MAD 12:45 16h 40m 1 Stop (MIA) Miami
      • PTYPanama City Tocumen International Airport 13:05
        MIAMiami International Airport 22:05
      • MIAMiami International Airport 17:05
        MADMadrid Barajas Airport 12:45
      • 16h 40m (5h)
      • 1 Stop MIA · Miami 5h
      • American Airlines (AA 2964)Airbus
        Iberia (IB 338)Airbus
      • American Airlines (AA 2964)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 13:15 PTY
        12:45 MAD
        16Hrs, 30m 1 Stop (MIA)
      • PTYPanama City Tocumen International Airport 13:15 - MAD 12:45 16h 30m 1 Stop (MIA) Miami
      • PTYPanama City Tocumen International Airport 13:15
        MIAMiami International Airport 22:05
      • MIAMiami International Airport 17:15
        MADMadrid Barajas Airport 12:45
      • 16h 30m (4h 50m)
      • 1 Stop MIA · Miami 4h 50m
      • American Airlines (AA 2964)Boeing 737 800
        Iberia (IB 338)Airbus
      • American Airlines (AA 2964)
        • M
        • T
        • W
        • T
        • F
        • -
        • S
      • 21:35 BOG
        16:55 MDE
        15Hrs, 25m 1 Stop (MAD)
      • BOGBogota Airport 21:35 - MDE 16:55 15h 25m 1 Stop (MAD) Madrid
      • BOGBogota Airport 21:35
        PTYPanama City Tocumen International Airport 15:40
      • MADMadrid Barajas Airport 14:05
        MDEMedellin Jose Maria Cordova Intl Airport 16:55
      • 15h 25m (3h 42m)
      • 1 Stop MAD · Madrid 3h 42m
      • Avianca (AV 10)Boeing 787 8
        Avianca (AV 317)Airbus
      • Avianca (AV 10)
        • -
        • T
        • W
        • T
        • F
        • S
        • S
      • 15:40 PTY
        15:30 MAD
        16Hrs, 50m 1 Stop (MDE)
      • PTYPanama City Tocumen International Airport 15:40 - MAD 15:30 16h 50m 1 Stop (MDE) Medellin
      • PTYPanama City Tocumen International Airport 15:40
        MDEMedellin Jose Maria Cordova Intl Airport 23:00
      • MDEMedellin Jose Maria Cordova Intl Airport 16:55
        MADMadrid Barajas Airport 15:30
      • 16h 50m (6h 05m)
      • 1 Stop MDE · Medellin 6h 05m
      • Avianca (AV 317)Airbus
        Avianca (AV 16)Boeing 787 8
      • Avianca (AV 317)
        • M
        • -
        • W
        • -
        • F
        • -
        • S
      • 21:35 BOG
        16:55 MDE
        15Hrs, 25m 1 Stop (MAD)
      • BOGBogota Airport 21:35 - MDE 16:55 15h 25m 1 Stop (MAD) Madrid
      • BOGBogota Airport 21:35
        PTYPanama City Tocumen International Airport 15:40
      • MADMadrid Barajas Airport 14:05
        MDEMedellin Jose Maria Cordova Intl Airport 16:55
      • 15h 25m (3h 42m)
      • 1 Stop MAD · Madrid 3h 42m
      • Avianca (AV 10)Boeing 787 8
        Avianca (AV 317)Airbus
      • Avianca (AV 10)
        • M
        • -
        • -
        • -
        • -
        • -
        • -
      • 17:25 PTY
        14:05 MAD
        13Hrs, 40m 1 Stop (BOG)
      • PTYPanama City Tocumen International Airport 17:25 - MAD 14:05 13h 40m 1 Stop (BOG) Bogota
      • PTYPanama City Tocumen International Airport 17:25
        BOGBogota Airport 21:35
      • BOGBogota Airport 18:55
        MADMadrid Barajas Airport 14:05
      • 13h 40m (2h 40m)
      • 1 Stop BOG · Bogota 2h 40m
      • Avianca (AV 61)Airbus
        Avianca (AV 10)Boeing 787 8
      • Avianca (AV 61)
        • M
        • T
        • W
        • T
        • F
        • S
        • S
      • 23:00 MDE
        18:55 BOG
        15Hrs, 05m 1 Stop (MAD)
      • MDEMedellin Jose Maria Cordova Intl Airport 23:00 - BOG 18:55 15h 05m 1 Stop (MAD) Madrid
      • MDEMedellin Jose Maria Cordova Intl Airport 23:00
        PTYPanama City Tocumen International Airport 17:25
      • MADMadrid Barajas Airport 15:30
        BOGBogota Airport 18:55
      • 15h 05m (3h 08m)
      • 1 Stop MAD · Madrid 3h 08m
      • Avianca (AV 16)Boeing 787 8
        Avianca (AV 61)Airbus
      • Avianca (AV 16)
        • M
        • -
        • W
        • -
        • F
        • -
        • S
      • 18:50 PTY
        16:25 MAD
        14Hrs, 35m 1 Stop (AMS)
      • PTYPanama City Tocumen International Airport 18:50 - MAD 16:25 14h 35m 1 Stop (AMS) Amsterdam
      • PTYPanama City Tocumen International Airport 18:50
        AMSAmsterdam Airport 13:50
      • AMSAmsterdam Airport 12:10
        MADMadrid Barajas Airport 16:25
      • 14h 35m (1h 40m)
      • 1 Stop AMS · Amsterdam 1h 40m
      • KLM (KL 758)Boeing 777 300 Er
        KLM (KL 1505)Boeing 737
      • KLM (KL 758)
        • M
        • T
        • W
        • T
        • F
        • S
        • S
      • 18:50 PTY
        19:30 MAD
        17Hrs, 40m 1 Stop (AMS)
      • PTYPanama City Tocumen International Airport 18:50 - MAD 19:30 17h 40m 1 Stop (AMS) Amsterdam
      • PTYPanama City Tocumen International Airport 18:50
        AMSAmsterdam Airport 16:55
      • AMSAmsterdam Airport 12:10
        MADMadrid Barajas Airport 19:30
      • 17h 40m (4h 45m)
      • 1 Stop AMS · Amsterdam 4h 45m
      • KLM (KL 758)Boeing 777 300 Er
        KLM (KL 1507)Boeing 737
      • KLM (KL 758)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 18:50 PTY
        19:30 MAD
        17Hrs, 40m 1 Stop (AMS)
      • PTYPanama City Tocumen International Airport 18:50 - MAD 19:30 17h 40m 1 Stop (AMS) Amsterdam
      • PTYPanama City Tocumen International Airport 18:50
        AMSAmsterdam Airport 16:55
      • AMSAmsterdam Airport 12:10
        MADMadrid Barajas Airport 19:30
      • 17h 40m (4h 45m)
      • 1 Stop AMS · Amsterdam 4h 45m
      • KLM (KL 758)Boeing 777 300 Er
        KLM (KL 1507)Boeing 737 800
      • KLM (KL 758)
        • M
        • T
        • W
        • T
        • -
        • -
        • S
      No Schedules Sorry, there are no schedules matching your filters. Try removing one. reset
      What’s the fastest flight time from Panama City to Madrid?

      The fastest flight time for direct flights from Panama City to Madrid is 9 hours 50 minutes. Check latest flight schedules & prices on Wego.

      What’s the most popular airline flying from Panama City to Madrid?

      The most popular airline flying from Panama City to Madrid is Air Europa. Find the latest flight deals on Wego.

      How far is Madrid from Panama City?

      The flight distance between Panama City and Madrid is 8163km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 03:20. The last flight of the day departs at 19:40. See the full list of flight times on Wego.

      How many airlines offer direct flights from Panama City to Madrid?

      There are 2 airlines that offer direct flights from Panama City to Madrid. Find out the list of airlines on Wego.

      All Airports in Madrid

      Madrid Barajas Airport MAD

      Popular Airlines Flying From Panama City to Madrid

      Air Europa ‏()

      Popular Destinations From Madrid

      Popular Destinations From Panama City

      Popular Hotels in Madrid

      Hotels In Popular Destinations